Nanashi's ninth manga volume of Don't Toy With Me, Miss Nagatoro revealed in its cover image that the anime has been listed for April 2021 release, and also revealed the cast for the anime.
The cast includes- Daiki Yamashita as Senpai, Mikako Komatsu as Gamo-chan, Aina Suzuki as Yosshii, Shiori Izawa as Sakura.
The anime's staff previously announced that Sumire Uesaka would voice the titular heroine Nagatoro.
The story description is as follows:
"When an introverted male student meets a girl called Nagatoro, his life is turned upside down. She first quietly observes his reaction to verbal abuse from some other high-school girls that are not well-meaning, realizes that oddly enough in his case it may be exactly what he needs, and so begins a sequence of her teasing him. It soon becomes increasingly obvious (to the reader, not to him) that her teasing is actually sardonic, well-intentioned, and flirtatious, but he eventually starts to catch on."
The series will be directed by Hirokazu Hanai at Telecom Animation Film, with Taku Kishimoto supervising scripts, Misaki Suzuki designing the characters, and Gin composing the music.
Nanashi started posting his manga and artworks through Pixiv. Don't Toy With Me, Miss Nagatoro is currently serialized through Magazine Pocket, since November 1, 2017, published by Kodansha. The manga has been licensed by Vertical in North America and the first volume was released in November 2019.